The present study was undertaken with a view to validate the traditional use of Boerhaavia diffusa root and Silybum marianum seeds in combination as a hepatoprotective agent against non alcoholic fatty liver disease. The alcoholic extracts of Boerhaavia diffusa roots (150 mg / kg, p. o.) and Silybum marianum (150 mg / kg, p. o.) seeds were administered to the experimental rats individually, and in combination (75 mg / kg + 75 mg /kg), p. o. by dispersing it in 1% Tween 80, were given, of different groups respectively. After intoxication with High fructose diet (HFD) fructose solution to the animals orally for six weeks serum levels of various enzymes were recorded. Serum levels of aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), total bilirubin, total protein and cholesterol level were assessed. Boerhaavia diffusa roots and Silybum marianum seeds extracts and silymarin exhibited a significant hepatoprotective effect as evident from the decreases of serum AST, ALT, ALP, TB and cholesterol and increases in levels of TP compared with control group (P<0.01 or P<0.05). The effect of combination of both the extract exerts more hepatoprotective as revealed by more level of significance. The present finding suggests that the hepatoprotective effect of Boerhaavia diffusa roots and Silybum marianum seeds extract.
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